NATURAL PRODUCTS TARGETING NITRIC OXIDE AS A THERAPEUTIC STRATEGY FOR TREATMENT OF HYPERTENSION: A REVIEW

Received 2023-10-30; Accepted 2024-04-19; Published 2025-01-02

Authors

  • Norasikin Ab Azis Department of Pharmacology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, 47000 Selangor, Malaysia.
  • Effendi Ibrahim Department of Physiology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, 47000 Selangor, Malaysia.
  • Harbindarjeet Singh Department of Physiology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, 47000 Selangor, Malaysia.
  • Wu Yuan Seng Sunway Microbiome Centre, School of Medical and Life Sciences, Sunway University, Subang Jaya, 47500 Selangor, Malaysia.
  • Nor Hisam Zamakshshari Department of Chemistry, Faculty of Resources Science and Technology, University Malaysia Sarawak, Kota Samarahan, 94300 Kuching, Sarawak, Malaysia.
  • Srinivasa Rao Sirasanagandla Department of Human & Clinical Anatomy, College of Medicine & Health Sciences, Sultan Qaboos University, PO Box 35, PC 123, Al-Khoud, Muscat, Oman.
  • Choy Ker Woon Department of Anatomy, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, 47000 Selangor, Malaysia.

DOI:

https://doi.org/10.22452/jummec.vol28no1.2

Keywords:

Natural products, Hypertension, Antihypertensive, Nitric Oxide signalling

Abstract

Hypertension remains a significant global health challenge, necessitating the exploration of novel therapeutic strategies. Nitric oxide (NO) signaling plays a pivotal role in blood pressure regulation, making it an attractive target for hypertension management. Natural products have garnered considerable attention for their potential to modulate NO signaling pathways and mitigate hypertension. This review provides a comprehensive overview of natural products targeting NO as a therapeutic strategy for hypertension treatment. We systematically examine the mechanisms by which natural compounds enhance NO bioavailability, promote vasodilation, and exert antihypertensive effects. Key natural products are evaluated for their efficacy in preclinical studies. Furthermore, we discuss the challenges and limitations associated with translating preclinical findings to clinical practice. Overall, this review highlights the promising role of natural products in modulating NO signaling pathways and offers insights into their potential as adjunctive therapies for hypertension management. Further research is warranted to elucidate the optimal dosing regimens, long-term effects, and potential drug interactions of natural compounds in diverse patient populations.

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Published

2025-01-02

Issue

Vol. 28 No. 1 (2025)

Section

Research article

License

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